Increasing complexity of socio-technical systems complicates cross-system product development in companies. In order to manage this complexity, company-related points of focus are becoming increasingly important. The aim of the joint project AMeLie is to efficiently design the product development of small and medium-sized enterprises (SMEs). This is done by a structured approach, which increases efficiency and thus competitiveness. For this purpose, conventional Systems Engineering (SE) approaches are transferred from theory into manageable methods. These methods can be individually combined to solve problems. In this way, development processes are to be shortened in the long term and SE is to become applicable for SMEs. Incurring costs should be reduced and the recertification process in the medical industry should also be manageable for SMEs.